![]() ![]() ![]() We used partial canonical correspondence analysis (pCCA) to examine the relative contribution of insomnia, based on actigraphic sleep efficiency (SE) and ISI, and of cognitive status, based on the Multitasking test of Median Reaction Latency (MTTLMD) and the Spatial Working Memory Between Errors (SWMBE), to variance in microbiota composition. Objective sleep quality was monitored by a two-week actigraphic recording, and participants completed the Insomnia Severity Index (ISI). Cognition was assessed with the Cambridge Neuropsychological Test Automated Battery. ![]() ![]() Microbiota profile was determined using the DADA2 bioinformatics pipeline. Patients and Methods: Seventy-two older adults with insomnia (age 73.2 ± 5.73 years, 56 females) provided stool samples for gut microbial sequencing. We tested associations between sleep quality and cognitive performance with gut microbiota in older adults with insomnia. A growing literature suggests the importance of gut microbiota for brain function. The mechanism underlying this comorbidity is not fully understood. Purpose: Insomnia, a chronic condition affecting 50% of older adults, is often accompanied by cognitive decline. *These authors contributed equally to this workĬorrespondence: Iris Haimov, Department of Psychology and the Center for Psychobiological Research, the Max Stern Yezreel Valley College, Yezreel Valley, 1930600, Israel, Email Iris Haimov, 1, * Faiga Magzal, 2, 3, * Snait Tamir, 2, 3 Maya Lalzar, 4 Kfir Asraf, 1 Uzi Milman, 5 Maayan Agmon, 6, * Tamar Shochat 6, *ġDepartment of Psychology and the Center for Psychobiological Research, The Max Stern Yezreel Valley College, Yezreel Valley, Israel 2Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Research Institute, Kiryat Shmona, Israel 3Nutritional Science Department, Tel Hai College, Kiryat Shmona, Israel 4Bioinformatics Service Unit, University of Haifa, Haifa, Israel 5Clinical Research Unit, Clalit Health Services, Haifa, Israel 6The Cheryl Spencer Department of Nursing, University of Haifa, Haifa, Israel ![]()
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